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Interior Design

Monday, August 24, 2009

Obesity as a Metabolic Disease

The reason weight-loss medications can’t provide any real results is that we have a complex, overlapping system of checks and balances that help "defend" our body-weight set point. Many different genes contribute to your body weight, and thus it’s impossible to manipulate it by focusing on just one hormone (or other substance). Others will jump in to compensate. The brief explanation of leptin and the other major players in this defensive strategy barely skims the surface of this intricate system. The take-home message is that these factors are beyond your conscious control. Our broader understanding of these factors has dramatically changed the framework of how we view the problem of weight gain and obesity. Instead of thinking of obesity as the consequence of a lack of restraint or willpower, it’s now increasingly recognized as a disease that results from a breakdown in the body’s normal system of checks and balances.



Source: George L. Blackburn, M.D., Ph.D., "Break Through Your Set Point: How to Finally Lose the Weight You Want and Keep It Off," 2008

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